Health
Keto diet linked to higher liver cancer risk
Eating a high-fat, low-carb diet could raise the risk of developing liver cancer within just twenty years, concerning new research has suggested.
Referred to as a ‘keto diet’, devotees claim that it can aid rapid weight loss without feelings of hunger—but experts now say fatty diets can fundamentally alter liver cells, increasing the risk of cancer.
US scientists found that when the liver is repeatedly exposed to a high-fat diet, its cells shift into a more primitive state.
Whilst this change helps cells withstand the stress caused by excess fat, it also makes them more vulnerable to disease.
‘If cells are forced to deal with a stressor such as a high fat diet over and over again, they will do things that will help them to survive, but at the risk of increased susceptibility to tumorigenesis [when normal cells mutate and become cancerous],’ Professor Alex Shalek, director of the Institute for Medical Engineering and Sciences, and study co-author, explained.
The team hopes that by targeting these changes early, doctors will be able to reduce the risk of tumour formation in people who are particularly vulnerable.
A keto diet involves almost entirely avoiding ingesting carbohydrates in order to trigger a state of ketosis, which is when the body burns stored fat for energy, which in turn helps people lose weight.
Carbohydrates are a macronutrient (along with fat and protein) and are found in everything from grains to starchy vegetables and fruits.
High-fat diets have long been linked to steatotic liver disease, whereby excess fat builds up inside the liver causing inflammation, liver failure and ultimately cancer.
In the study, published in the journal Cell, researchers fed mice a high-fat diet and used cell-sequencing to analyse how their livers responded.
Early on, liver cells called hepatocytes were shown to activate genes to help them survive- reducing the likelihood of cell death and promoting growth.
However, at the same time, genes essential for normal liver function were shut down.
‘This really looks like a trade-off, prioritising what’s good for the individual cell to stay alive in a stressful environment, at the expense of what the collective tissue should be doing,’ Constantine Tzouanas, Harvard-MIT graduate and study co-author said.
By the end of the study, nearly all mice fed a high-fat diet had developed liver cancer.
The researchers found that when liver cells adapt in this way, they are more likely to become cancerous if a damaging mutation later occurs.
Tzouanas said: ‘These cells have already turned on the same genes that they’re going to need to become cancerous.
‘Once a cell picks up the wrong mutation, then it’s really off to the races and they’ve already got a head start on some of those hallmarks of cancer.’
After uncovering these cellular changes in mice, the team turned their attention to people with various stages of liver disease.
They found that, over time, genes required for normal liver function deteriorated, while genes linked to cell survival thrived, allowing them to accurately predict patient survival outcomes.
‘Patients who had higher expression of these pro-cell-survival genes that are turned on with a high-fat diet survived for less time after tumours developed,’ Tzouanas explains.
‘And if a patient has lower expression of genes that support the functions that the liver normally performs, they also survive for less time.
The scientists highlighted that whilst most of the mice developed cancer within a year, this process is much slower in humans, unfolding over around 20 years.
But, they added, this time frame can vary based on lifestyle factors such as alcohol consumption, and overall health – with excessive drinking and viral infections both pushing liver cells toward an ‘immature’ state, increasing the risk of cancer.
This is because when liver cells exist in a less mature state, they are more likely to become cancerous if a damaging mutation occurs later.
The team will now investigate whether this damage can be reversed through a healthier diet, or using GLP-1 weight loss drugs such as Mounjaro.
Prof Shalek said: ‘We now have all these new molecular targets and a better understanding of what is underlying the biology, which could give us new angles to improve outcomes for patients.’
A keto diet often consists of 75 per cent fat, 20 per cent protein and only 5 per cent carbohydrates.
By contrast, the NHS’s healthy balanced diet advice advocates for 30 per cent fat, 15 per cent protein and over 50 per cent carbohydrates.
Despite multiple studies pointing to the potential dangers of a keto diet it has become increasingly popular. A number of celebrities such as Gwyneth Paltrow, Jennifer Aniston, Halle Berry and Kourtney Kardashian have spoken about being on the low-carb diet in the past.
Where liver disease was once largely confined to the elderly and heavy drinkers, it is now rising rapidly among younger adults.
The British Liver Trust estimates the condition may now affect one in five people in the UK—though experts have warned the true figure could be as high as 40 per cent.
Worryingly, around 80 per cent of those affected remain undiagnosed, as the disease often has no obvious symptoms—or it has symptoms that are mistaken for less serious problems.
Around one in four patients will develop a more advanced form of the disease resulting in irreversible scarring of the liver, ultimately resulting in organ failure and cancer.
But experts are hopeful that weight loss jabs like Mounjaro will transform liver disease treatment, helping the liver burn excess fat that increases the risk of disease.
Daily Mail
Health
NMC Royal Hospital, Mohammed Bin Zayed City, Successfully Treats Lifelong Complications from Childhood Surgery
Advanced Reconstructive Surgery Helps Patient Regain Normal Urinary Function After Years of Complications
Abu Dhabi, UAE – A specialist urology team at NMC Royal Hospital, Mohammed Bin Zayed City, led by Dr. Rami Labib, Urologist, has successfully helped a 30-year-old patient regain normal urinary function after years of complications linked to a surgery he underwent as a child.
For many years, the patient experienced difficulty urinating and persistent urine leakage through small openings along the penis. The condition significantly affected his daily life, causing discomfort, embarrassment and a loss of confidence.
The complications were related to hypospadias, a condition present at birth in which the opening of the urethra is not located at the tip of the penis. While hypospadias is commonly corrected during childhood and most patients achieve excellent long-term results, a small number may develop complications later in life that require further treatment.
After a detailed assessment, Dr. Labib identified narrowing of the urethra, known as a urethral stricture, along with abnormal passages that were causing urinary leakage. Imaging tests confirmed the diagnosis and helped the team plan the most appropriate treatment.
To restore normal function, Dr. Labib performed a highly specialised reconstructive procedure known as a buccal mucosal graft urethroplasty. The surgery used a small piece of tissue taken from the inside of the patient’s cheek to rebuild the damaged section of the urethra and close the abnormal openings responsible for the leakage.
Commenting on the case, Dr. Rami Labib said:
“Patients who experience complications years after hypospadias repair often face significant physical and emotional challenges. Every case is different and requires careful planning to achieve the best outcome. Modern reconstructive techniques allow us to restore normal urinary function and help patients return to their daily lives with greater comfort and confidence.”
The operation was completed successfully, and the patient made a good recovery. During follow-up visits, he reported being able to urinate normally without any leakage and described a substantial improvement in his overall quality of life.
Expressing his gratitude, the patient said:
“After years of struggling with urinary problems following multiple surgeries, I can finally urinate normally again without any leakage. I am extremely grateful to Dr. Rami and the entire medical team for restoring my confidence and giving me my life back.”
Dr. Labib noted that advances in reconstructive urology continue to improve outcomes for patients with even the most complex conditions. With expert assessment, personalised treatment plans, and modern surgical techniques, many patients can achieve long-lasting relief and return to everyday activities with confidence.
About NMC Royal Hospital
NMC Royal Hospital is one of Abu Dhabi’s leading tertiary healthcare institutions, providing comprehensive medical and surgical services through highly specialised clinical teams and advanced technology. The hospital offers expertise across a wide range of specialties, including reconstructive urology, with a commitment to delivering safe, high-quality, patient-centred care.
Health
Fakeeh University Hospital Brings New Hope to Patients with Complex Brain Conditions Through Advanced MRI-Guided Laser Neurosurgery
Russian teenager with high-risk brainstem tumour successfully undergoes minimally invasive laser treatment in Dubai
Dubai, UAE – June 2026 – Fakeeh University Hospital has successfully performed an advanced MRI-guided Laser Interstitial Thermal Therapy (LITT) procedure on a 15-year-old patient from Russia suffering from a brainstem glioma, one of the most challenging and high-risk brain tumours encountered in neurosurgery.
The young patient travelled to Dubai after conventional oncology treatments failed to halt the progression of the disease. The tumour, located deep within the brainstem, had caused progressive neurological deterioration, including worsening motor deficits and paralysis, significantly affecting his quality of life and presenting a complex therapeutic challenge.
Following extensive multidisciplinary discussions involving neurosurgery, neuro-oncology, radiology, and rehabilitation specialists, the medical team at Fakeeh University Hospital carefully evaluated all available treatment options. Given the tumour’s location within one of the most delicate regions of the brain, traditional open surgery was associated with exceptionally high risks.
The brainstem controls many of the body’s most vital functions, including movement, breathing, heart rate, and consciousness. Surgical intervention in this area has historically carried substantial risks, including permanent paralysis, respiratory failure, and even cardiac arrest.
To minimize these risks while offering a potential treatment option, the team elected to perform MRI-guided Laser Interstitial Thermal Therapy (LITT), a highly advanced minimally invasive neurosurgical technique increasingly used worldwide for carefully selected patients with deep-seated brain lesions.
The procedure was led by Dr. Tommaso Tufo, Consultant Neurosurgeon – Brain and Spine Surgery at Fakeeh University Hospital, using a stereotactic robotic-assisted approach. Through a small skin incision measuring only a few millimetres, a laser fibre was precisely implanted into the target area using advanced robotic guidance and neuronavigation technology.
The implantation phase lasted just over one hour, after which the patient was transferred to the MRI suite. Under continuous real-time MRI monitoring, laser thermal therapy was delivered over the course of approximately one to two hours, allowing surgeons to visualize the thermal effect in real time and precisely control the treatment zone throughout the procedure.
One of the most significant advantages of MRI-guided laser therapy is its ability to reach deep and difficult-to-access areas of the brain while minimizing disruption to surrounding healthy tissue. Real-time MRI thermal mapping provides exceptional precision, allowing surgeons to perform controlled volumetric reduction of tumours without the need for extensive surgical exposure.
Commenting on the case, Dr. Tommaso Tufo said:
“Brainstem tumours represent some of the most challenging conditions in neurosurgery because of their location within structures that control critical neurological and physiological functions. In this particular case, conventional treatment options had become limited, and traditional open surgery carried considerable risks. MRI-guided laser therapy allowed us to reach the lesion through a minimally invasive approach while maintaining a very high degree of precision and safety.”
He added:
“The successful treatment of this patient demonstrates the potential of modern laser neurosurgery to expand therapeutic options for carefully selected patients who may previously have had very limited alternatives. However, the true significance of this technology extends far beyond a single case.”
While the patient continues to undergo physiotherapy and additional oncological treatment as part of his ongoing care, he tolerated the procedure well and was able to resume mobility following treatment.
Dr. Tufo emphasized that MRI-guided Laser Interstitial Thermal Therapy should be viewed within the broader context of modern neurosurgery rather than as a solution limited to rare brainstem tumours.
“Laser neurosurgery represents an important advancement in the treatment of selected brain tumours, drug-resistant epilepsy, radiation necrosis, and other complex intracranial conditions,” he explained. “The technology allows us to treat lesions located deep within the brain through a very small incision while minimizing trauma to surrounding tissue. Both adult and pediatric patients may benefit from this approach when conventional surgery presents excessive risk.”
Historically, many patients with drug-resistant epilepsy required open cranial surgery to access and remove seizure-causing areas of the brain. Today, in selected cases, MRI-guided laser ablation offers a less invasive alternative that combines precision, safety, and shorter recovery times.
For appropriately selected patients, the minimally invasive nature of the procedure may significantly reduce hospitalization and recovery periods, with some individuals able to return home on the same day or within 24 hours. More complex cases, particularly those involving critical brain structures, may require extended monitoring to ensure optimal neurological recovery.
The introduction of advanced MRI-guided laser neurosurgery further strengthens Fakeeh University Hospital’s position as a regional center of excellence for complex neurological and neurosurgical care. By combining advanced imaging, robotic guidance, and minimally invasive techniques, the hospital continues to expand access to innovative treatment options for patients facing some of the most challenging brain conditions.
About Fakeeh University Hospital
Fakeeh University Hospital is a leading academic medical center located in Dubai Silicon Oasis and part of Fakeeh Health. The hospital combines advanced clinical care, medical education, research, innovation, and digital health technologies to deliver world-class healthcare services. Through continuous investment in cutting-edge medical technologies and multidisciplinary expertise, Fakeeh University Hospital remains committed to advancing patient care and improving outcomes across a wide range of complex medical conditions.
For more information, visit: Fakeeh Health – Advancing Healthcare with Excellence
Health
Paris Hilton Optimizes Home for ADHD
Ever since being diagnosed with ADHD in her twenties, Paris Hilton has chosen to see her neurodiversity as her “superpower.”
“I wouldn’t be the person that I am today without it,” Hilton, 44, tells PEOPLE. The DJ, model, Parívie founder, TV star, author, fashion designer, and founder of the next-gen media company, 11:11, is a champion for neurodiversity and inclusion. It’s why she opened her front doors — literally — for a three-part video series on how she optimized her home and office for herself and team members with ADHD.
In Inclusive by Design, Hilton teams up with experts Sarah Greenberg and Dr. Andrew Kahn from Understood.org, a leading nonprofit that supports people with learning differences, as well as Android and the nonprofit arm of her company, 11:11 Media Impact. The series explains how she made her closet, craft room, and home office workable for herself and members of her 11:11 team, many of whom have neurodiversity.
Hilton shares with PEOPLE why she’s chosen to be so open about her ADHD journey — and what drives her to be an advocate.
What made you decide to share such an intimate part of your life for this series?
“I just really wanted to share strategies and different things that I’ve learned from managing my ADHD, both in my personal and professional life, and I really hope by sharing my experiences it can help reduce the stigma of ADHD and make neurodiversity relatable,” Hilton tells PEOPLE.
“I’ve just seen how so many people who think differently feel so alone, so I really wanted to create space and just show how I’m embracing and harnessing my ADHD, and they can, too.”
What can parents of a neurodivergent child do at home to help?
“You come out in the world, there’s just so many distractions and things happening, and it’s a lot on someone,” Hilton says, sharing that a person with neurodivergence will appreciate “a space that makes them feel happy and just able to decompress and feel their best.”
She tells PEOPLE that her own motherhood journey — she shares son Phoenix Barron, 2, and daughter London Marilyn, 23 months, with husband Carter Reum, 44 — has influenced her advocacy.
“Motherhood has given me a whole new purpose and I want my kids to grow up feeling celebrated for who they are. I feel like the only way to do that is to fully embrace myself first so that I can be the best, most authentic mom for them.”
Was there anything that surprised you as being helpful to ADHD as you worked on these spaces?
“With ADHD there’s something called object permanence, where, like, if you don’t see something, it basically doesn’t exist in your mind. So visual organization is so important.”
So she organized her craft room with clear drawers so she can see what’s inside. And in her closet, the cabinets and drawers that aren’t glass-paneled have labels explaining what’s inside.
As Hilton explains, she needs to “have it labeled so I can see everything and then my brain will start to remember where each thing is.”
When you redesigned your office, you found a chair that helps people with ADHD. How does a small touch like that make a difference?
“It’s comfortable, it can move around in any position, so you could just be like sitting on it, you could be leaning on it … sometimes with ADHD it’s hard to like just sit still,” she explains. “You just like feel more relaxed, you can focus easier.”
What is the biggest misconception about ADHD?
“People need to understand the positive parts about it,” she says, adding that many artists, actors, singers, creators, and scientists have been diagnosed with ADHD. “There’s so many brilliant people in the community that I think should be celebrated more, and people need to know because that’s such an inspiration to other kids. I want to continue getting that message out as well, so people can feel celebrated and not feel bad about something that they shouldn’t feel bad about.”
You’ve talked about masking your ADHD when you were younger. Can you explain why masking can be so hard?
“For me growing up, like no one was talking about ADHD,” Hilton says, explaining that when she was in school, “it was so difficult for me to remember things. I would constantly lose my homework get in trouble with the teachers.”
“I just felt like something was wrong with me and I’d just be sad, but then I would just mask or, like, kind of try to act like nothing’s wrong on the inside … I was just going through so many emotions, and after speaking to so many others with ADHD, I can totally understand it now. It’s exhausting having to do that and to feel that way.”
Now, she says, “I’m learning so much and I just wish that I knew all I know now, back when I was a kid growing up in school, but I’m doing this for the little girl in me … now I see it as a superpower, and I wouldn’t be the person that I am today without it. I’m such a creator. I’m constantly thinking of new ideas.”
As Hilton says, “I just want people to understand that you’re not broken. It’s just your brain is wired for something different and something very special, so I just want people to know that. It’s not a weakness. It can actually be a superpower if you can harness it in the right way.”
People
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