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Health

Doctors hint at radical change in bowel cancer treatment – thousands of patients might not need chemo

From Dailymail UK

Thousands of patients with an advanced form of bowel cancer may not need chemotherapy, scientists suggested today. 

Just under a third of all bowel cancers are diagnosed at stage three, meaning it has spread into nearby lymph nodes but not other parts of the body.

Under current UK guidance, stage three treatment involves surgery to remove the tumour followed by chemotherapy to reduce the risk of the cancer returning. 

But Australian researchers discovered that undertaking a ‘state-of-the-art’ blood test after surgery could determine if patients only need a reduced dose of chemotherapy or even no chemotherapy at all. 

The test, known medically as a ctDNA test, looks for tiny fragments of tumour DNA circulating in the bloodstream. 

Assessing patients who had ctDNA-negative results following surgery, scientists compared the outcomes of those who were given a reduced dose of chemotherapy or no chemo at all against those given standard treatment. 

They found patients on the lower dose of treatment — mainly those with ‘low risk’ stage three tumours — dramatically reduced their risk of suffering side effects and some were at no higher risk of developing a more invasive form of the cancer. 

Experts today, who labelled the findings ‘highly important’, said the test would ‘likely’ influence how patients are treated over the coming years, but warned that further research was vital. 

It comes amid a disturbing rise in bowel cancer cases—also known as colon cancer—in under 50s has baffled doctors around the globe. 

The disease—which also claimed the life of Dame Deborah James at the age of 40—has surged by 50 per cent this age-group over the past three decades. 

In the groundbreaking trial, researchers tracked almost 1,000 patients with stage three bowel cancer who underwent a ctDNA test five or six weeks after surgery. 

They found 702 were ctDNA-negative and of these 353 patients underwent reduced chemotherapy treatment. 

Over a follow-up of three and a half years, they found just 6.2 per cent suffered severe side effects compared to 10.6 per cent on standard treatment. 

Treatment-related hospitalisations were also lower, with 8.5 per cent requiring treatment compared to 13.2 per cent on standard treatment.  

However, the results also showed that the ctDNA test alone was insufficient to determine which patients did not require chemotherapy without risking under-treatment.

But, a subgroup analysis of patients with low-risk stage three tumours — where only three lymph nodes were positive for the disease — found the approach was ‘non-inferior’.

Medically, this means a new treatment is not unacceptably worse than an existing one, even if it’s not proven to be more effective. 

‘Stage three colon cancer patients with negative post-surgery ctDNA results had a low recurrence risk,’ the researchers from the Peter MacCallum Cancer Centre in Melbourne, said. 

‘ctDNA guided de-escalation is feasible’, they added, ‘especially for clinical low-risk tumours’. 

The results of the trial will be presented in full at the European Society of Medical Oncology annual congress in Berlin.

Professor Marco Gerlinger, a consultant medical oncologist at St Bartholomew’s Hospital in London, who was not involved in the research, also said: ‘A major problem in clinical practice is that we overtreat many patients, as 50 per cent have already been cured by surgery alone. 

‘Until recently, we had no tests to identify those patients who don’t need chemotherapy. 

‘This trial used a state-of-the-art high-sensitivity circulating tumour DNA test.

‘Although the trial is not practice changing for all stage three bowel cancers, it is highly important and will likely influence clinical practice. 

‘For low-risk stage three tumours, patients may make an informed decision to omit or reduce chemotherapy intensity if the test comes back negative — as the trial showed that this reduces severe side effects. 

‘But further trials are needed to confirm these results and to determine how circulating tumour DNA and other risk approaches need to be combined to tailor chemotherapy to the patient’s preferences and risk of recurrence.’ 

There are around 44,000 cases of bowel cancer every year in the UK and 142,000 in the US, making it the fourth most common cancer in both countries.

Symptoms often include changes in bowel movements such as consistent and new diarrhoea or constipation, needing or feeling the need to poo more or less frequently and blood in the stool.

Stomach pain, a lump in the stomach, bloating, unexpected weight-loss and fatigue are among other signs.

Anyone experiencing these symptoms should contact their GP for advice. 

Although the vast majority of bowel cancer diagnoses affect those aged over 50, rates in older age-groups has either declined or held stable while diagnoses in younger adults have risen by 50 per cent over the last 30 years.

Cancer Research UK estimates that over half (54 per cent) of bowel cancer cases in the UK are preventable. 

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Health

Safe Blood Donation Before, During, and After Ramadan – Medical Guidelines by Dr. Ganesh Dhanuka

By Dr. Ganesh Dhanuka
Specialist Internal Medicine and Nephrology
International Modern Hospital


Blood donation remains one of the most impactful humanitarian acts, capable of saving multiple lives with a single unit of blood. However, during the holy month of Ramadan, many individuals question whether it is safe to donate while fasting and how to properly prepare for donation.

From a medical standpoint, blood donation is generally safe for healthy individuals. Nevertheless, appropriate preparation — especially in the context of fasting — is essential to minimize risks such as dizziness, dehydration, or hypotension.

This article outlines evidence-based recommendations for blood donation before, during, and after Ramadan, along with its physiological, psychological, and societal benefits.


Preparing for Blood Donation Before Ramadan

Proper preparation significantly reduces the risk of adverse effects during donation. Individuals planning to donate should:

Nutritional Preparation

Consume a balanced meal rich in iron and protein approximately 2–3 hours before donating. Iron-rich foods such as lean red meat, spinach, lentils, beans, and fortified cereals help maintain adequate hemoglobin levels. Protein supports plasma volume and recovery.

Avoid donating on an empty stomach, as this increases the likelihood of lightheadedness and vasovagal reactions.

Hydration Status

Adequate hydration is critical. Donors should:

  • Increase water intake the day before donation.
  • Drink extra fluids on the day of donation.

Proper hydration helps maintain blood pressure and reduces the risk of fainting.

Sleep and Lifestyle Factors

  • Ensure 6–8 hours of quality sleep the night before.
  • Avoid alcohol for at least 24 hours prior to donation.
  • Refrain from strenuous physical activity before donation.

Medical Disclosure

Bring valid identification and honestly disclose:

  • Any chronic medical conditions.
  • Current medications.
  • Recent illnesses or procedures.

Transparency ensures donor safety and protects recipients.


What to Expect During Blood Donation

The blood donation process is generally straightforward and takes about 10–15 minutes for the actual collection.

During donation:

  • Stay calm and breathe normally.
  • Avoid sudden movements.
  • Inform medical staff immediately if you experience dizziness, nausea, sweating, blurred vision, or weakness.
  • Follow all staff instructions carefully.

Most temporary reactions, when they occur, are mild and resolve quickly with rest and hydration.


Post-Donation Care and Recovery

The post-donation period is crucial for safe recovery.

Immediate Aftercare

  • Rest at the donation center for 10–15 minutes.
  • Accept fluids and light refreshments provided.
  • Avoid standing up abruptly.

The Next 24 Hours

  • Increase fluid intake significantly.
  • Consume iron-rich foods to replenish red blood cell production.
  • Avoid heavy lifting for 24 hours.
  • Avoid strenuous exercise on the same day.
  • Avoid alcohol for several hours after donation.

If dizziness occurs, lie down and elevate your legs until symptoms resolve.

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Food

Foods That Look Healthy for Weight Loss (But Actually Aren’t)

By Dr. Yara Husein (Food and Nutrition Expert)

Companies often use specific buzzwords on food labels to market products as healthy and weight-loss friendly options. In reality, these options can sometimes have the opposite effect. Here are some common foods and drinks that might be holding you back:

Fat-free dairy products

Many think that fat-free dairy products are ideal for dieting and do not contribute to weight gain. However, in truth, these products can cause weight gain because fat-free products are less satiating than their full-fat counterparts; fat is a nutrient that supports feelings of fullness and makes food more enjoyable. Furthermore, food manufacturers often replace fat with sugar in low-fat and fat-free products to compensate for the lost flavour. Beyond that, skimmed dairy products provide the body with fewer nutrients than full-fat products, because vitamins such as A, D, E, and K are fat-soluble vitamins that require fat to enter the body, be absorbed, and be utilized.

Gluten-free foods

While it is essential for people with gluten-related disorders to avoid gluten, gluten-free foods are not necessarily healthier than foods containing gluten. Some processed gluten-free foods and desserts contain the same amount of calories and added sugar—if not more—as other snacks. Studies, including a study published in the journal PeerJ, indicate that gluten-free snack foods tend to be lower in protein, fiber, and certain vitamins and minerals compared to their gluten-containing counterparts. They are also generally more expensive.

Breakfast cereals

Many people think that breakfast cereals are an ideal and healthy breakfast to start their day, but in reality, many cereals are made from refined grains that lack nutrients like protein and fiber, and they can contain a high percentage of added sugar. For example, Honey Nut Cheerios, which are marketed as heart-healthy, contain 12 grams of added sugar per cup. Eating large quantities of these and other cereals high in added sugar may lead to an increased risk of heart disease, high blood pressure, high triglyceride levels, and weight gain.

Energy and sports drinks

Companies market sports and energy drinks as ways to boost energy and athletic performance, but these drinks can contain a massive amount of sugar. Consequently, they can contribute to weight gain for people who consume them without performing intense physical exercise. For instance, a popular energy drink like Monster (473 ml) contains 54 grams of added sugar—a quantity much higher than the amount recommended by the American Heart Association (25g for women and 36g for men). Research, including a study published in the journal Pediatric Obesity, has linked the consumption of sweetened beverages to health problems, including high blood pressure, fatty liver, and obesity in children and adolescents.

Diet soda

When following a diet, many people may turn to sugar-free or calorie-free drinks, thinking they contribute to weight loss. However, studies indicate that diet soda may contribute to certain health problems by altering brain responses to food and increasing the desire to eat high-calorie foods such as sweets and fast food. A study published in the journal Nutrients linked the consumption of these drinks to a higher risk of metabolic syndrome, which is a group of symptoms that include increased belly fat, blood sugar, blood pressure, and blood lipid levels.

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Health

Excessive Screen Time in Children: Digital Eye Strain, Myopia Risk, and Long-Term Vision Health

By Dr. Tahere Rezaei
Ophthalmologist
International Modern Hospital Dubai


In today’s digital era, children are spending unprecedented hours on tablets, smartphones, and social media platforms. From a clinical perspective, the impact of excessive screen exposure on pediatric eye health is becoming increasingly evident.

Ophthalmology clinics are witnessing a clear rise in complaints linked directly to prolonged device use. Children often hold screens very close to their eyes and remain intensely focused for extended periods without taking breaks. This sustained near work places continuous strain on the visual system, particularly on the eye muscles responsible for focusing.

The most immediate and common consequence is digital eye strain. Symptoms typically include:

  • Headaches
  • Eye fatigue
  • Blurred vision
  • Burning sensation
  • Dryness due to reduced blinking

When children concentrate on screens, their blink rate significantly decreases. Reduced blinking leads to tear film instability, which contributes to dryness and irritation. Over time, persistent strain can affect visual comfort and academic performance.


Rising Concern: Childhood Myopia

Beyond temporary discomfort, there is a more serious long-term concern — the increasing prevalence of childhood myopia (short-sightedness).

Extended near work combined with limited outdoor exposure has been strongly associated with faster progression of myopia. Natural daylight and distance viewing play a protective role in visual development. When children spend most of their time indoors focusing on close objects, the eye adapts by elongating, leading to blurred distance vision.

Early-onset myopia is not simply about needing glasses. Higher degrees of myopia later in life increase the risk of:

  • Retinal detachment
  • Glaucoma
  • Myopic macular degeneration
  • Early cataracts

Preventing rapid myopia progression during childhood is therefore critical for long-term ocular health.


Screen Use and Sleep Disruption

Another clinically observed issue is the effect of screen exposure before bedtime. Blue light emitted from digital devices can suppress melatonin production, disrupting the natural sleep cycle. Poor sleep quality affects not only overall health but also visual comfort, concentration, and cognitive performance.

Children who use screens late at night frequently report:

  • Difficulty falling asleep
  • Morning eye discomfort
  • Increased fatigue during the day

Sleep plays a vital role in ocular surface recovery and overall neurological health.


Supporting Healthy Visual Development

For optimal eye development, children require balanced visual habits. Key preventive measures include:

  • Limiting continuous screen time
  • Encouraging daily outdoor activity
  • Maintaining proper room lighting
  • Ensuring appropriate screen distance
  • Practicing scheduled visual breaks (such as the 20-20-20 rule: every 20 minutes, look at something 20 feet away for 20 seconds)

Parents play a crucial role in modeling healthy screen behavior and establishing structured digital routines.

As Dr. Tahere Rezaei emphasizes, eye health in childhood directly influences long-term vision outcomes. Early awareness, prevention, and regular eye examinations are essential to protect children from avoidable visual complications in adulthood.

Healthy eyes today mean clearer vision for life.

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