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GLP-1 diabetes drugs could stop anxiety and depression

Diabetes drugs could prevent anxiety and depression from worsening, according to research.

Type 2 diabetes affects more than 800 million people globally and research shows that those with the condition are about twice as likely to have depression as the wider population.

GLP-1 receptor agonists such as semaglutide are commonly prescribed for diabetes and obesity. While studies have found other health benefits beyond weight loss and better blood sugar levels, the medications’ effects on mental health have been unclear.

International researchers examined Swedish health records of almost 95,000 people with a diagnosis of depression or anxiety who were also taking various diabetes medications between 2009 and 2022.

The study compared periods when patients were taking GLP1s, or other second-line diabetes medications, with when they were not taking them. Worsening mental health was assessed through data on psychiatric hospital admissions, sick leave from work due to mental health reasons, hospitalisation owing to self-harm and death by suicide. Published in the Lancet Psychiatry, the research also examined data on new diagnoses of anxiety and depression.

The authors found that semaglutide, the active ingredient in the drugs Ozempic for diabetes and Wegovy for weight loss, as well as liraglutide (Saxenda) were associated with a lower risk of worsening mental illness in those with anxiety and depression.

Semaglutide had a 42% lower risk of worsening mental health, while liraglutide was linked to an 18% lower risk. Other GLP-1 drugs, including exenatide and dulaglutide, did not show the same benefit.

Semaglutide was associated with a 44% lower risk of worsening depression, a 38% lower risk of worsening anxiety and a 47% lower risk of worsening substance use disorder.

“For anxiety and depression that co-occur with diabetes and obesity, semaglutide and, to a lesser extent, liraglutide might be useful dually effective therapeutic options,” the authors concluded.

Dr Markku Lähteenvuo, a research director at the University of Eastern Finland, said: “It is possible that, in addition to factors such as reduced alcohol consumption, weight loss-related improvements in body image, or relief associated with better glycaemic control in diabetes, there may also be direct neurobiological mechanisms involved, for example, through changes in the functioning of the brain’s reward system.”

Responding to the findings, experts urged caution, including Prof David Nutt, who is the head of the neuropsychopharmacology unit at Imperial College London and chair of the independent scientific committee Drug Science.

He said: “It is well established that better mental health tends to follow from better physical health and since the 1880s we have known that diabetes is associated with depression, although I think it’s unlikely that using GLP-1R agonists alone as treatments for depression or anxiety will work.”

Prof Eduard Vieta, a professor of psychiatry at the University of Barcelona and editor in chief of the European College of Neuropsychopharmacology journal, said: “From a clinical perspective, these findings are reassuring regarding the psychiatric safety of GLP-1 receptor agonists and suggest a potential role not only in preventing worsening but also, possibly, in improving mental health outcomes.

“However, they should not yet be interpreted as evidence of a direct therapeutic effect on depression or anxiety.”

The research came as a separate study found that women taking semaglutide for diabetes before they knew they were pregnant had a 84% higher relative risk of preterm birth, compared with those who did not take GLP-1 medication, while the risk was 70% higher with liraglutide.

Academics looked at Danish health registries for nearly 500,000 women, of whom 529 had been taking liraglutide or semaglutide when they became pregnant.

The study found that inadvertent exposure to GLP-1s in early pregnancy was associated with a higher risk of the baby being born before 37 weeks when the drugs were used for diabetes treatment, but not among those taking them for weight loss.

Taking semaglutide was associated with approximately a 11% higher absolute risk of preterm birth. Liraglutide showed a 9% increased risk.

The Guardian

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Saudi Arabia’s Tawakkalna app offers Hajj services in 19 languages

Saudi Arabia’s national digital platform Tawakkalna is providing Hajj-related government services in 19 languages for pilgrims and workers during the 1447H Hajj season, as part of wider efforts to improve the pilgrimage experience through advanced digital solutions.

The initiative comes within the efforts of the Saudi Data and Artificial Intelligence Authority to strengthen integration between government service entities during Hajj and support pilgrims throughout their journey, from arrival in the Kingdom and entry into Mecca and the holy sites to visits to the Prophet’s Mosque in Madinah and departure back to their home countries.

The app supports Arabic, English, Indonesian, Hindi, Urdu, Turkish, French, Bengali, Persian, Malay, Russian, Chinese, Filipino, German, Dutch, Japanese, Italian, Spanish and Portuguese.

Pilgrims can access a range of services through the platform, including Hajj permits linked to the unified digital Hajj permit platform “Tasreeh”, as well as permits related to entering Mecca, work authorisations, volunteer permits and vehicle permits issued by various government entities.

According to officials, Tawakkalna is designed to serve as a trusted digital companion for pilgrims by supporting daily movement and offering a smoother and safer digital experience during Hajj and visits to Madinah after the pilgrimage.

The app also allows users to book visits to Al Rawdah Al Sharifah through the Nusuk gateway service integrated into the platform.

Additional services available during Hajj include multilingual access to the Arafah sermon, an emergency assistance service called “Assefni”, live weather updates for the holy sites, Qibla direction, prayer times and digital Quran services.

Saudi authorities said the services are part of broader efforts aligned with the Pilgrim Experience Programme under Saudi Vision 2030, which prioritises improving services for pilgrims and Umrah performers through smart technology solutions.

The Tawakkalna platform currently offers more than 1,300 services in cooperation with over 350 government entities across sectors including health, education, justice, tourism and professional services, with more than 35 million users registered on the app.

GN

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Do your lungs regenerate after quitting smoking?


It used to be thought that the lungs couldn’t regenerate,” says Dr Charlotte Dean, head of the lung development and disease group at Imperial College London. “But we know now that’s not the case. Broadly speaking, they can repair when you quit smoking.”

Smoking is in effect damaging your lungs, Dean says, and the lungs have a substantial capacity to heal themselves. They have evolved to cope with pollution or getting infected by bacteria or viruses. “Because they’re so vital – you can’t survive without your lungs – they needed to have this capacity,” she says.

Dean says this shouldn’t be used as an excuse to smoke, though; smoking and vaping expose your lungs to more toxic particles than they can cope with. Importantly, everyone is different and some people’s lungs will not be able to regenerate as well as others and so will be much more susceptible to permanent tissue damage from smoking.

“While it’s broadly true that if you stop smoking you can revert to having much better lung health, it doesn’t mean you’re completely out of the woods. You may well have triggered mutations or genetic changes or tissue damage, and those things can affect your overall lung health, meaning that the decline as you age will come quicker or could lead to cancer.”

She would encourage smokers to quit as early as possible as – similarly to how your bones don’t mend as well as you age – your lung tissue gets less effective at repairing itself as you get older. A healthy lifestyle can help. “Exercise is really important,” says Dean. “Just like how when you exercise you keep your muscles healthy, in a way the lungs are the same. You build up the capacity for gas exchange to happen more effectively, to provide oxygen around the body.”

The Guardian

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Older than the dinosaurs

On a spring evening along the banks of the River Thames, thousands of mayflies can be seen engaging in what may be one of the world’s oldest dances. In the fading light, the males make a steep vertical climb, flip over and float back to Earth – wings and tail outstretched in a skydiving posture so as to drop slowly through the sky.

Mayflies are among the world’s oldest winged insects, emerging roughly 300m years ago – long before dinosaurs walked the Earth. Even the Mesopotamian poem the Epic of Gilgamesh, one of the oldest pieces of literature, makes reference to the short-lived mayfly. Over the epochs, the insect’s basic design has changed very little compared with the fossils of their ancestors.

“They have retained these odd characteristics and we can probably assume that they’ve been doing this [dance] for hundreds of millions of years, and yet we don’t really know why,” says Samuel Fabian, a research fellow at the University of Oxford who studies the aerial behaviours of insects.

Now, Fabian and his colleagues at Imperial College London think they finally have an answer. In new research published in the Journal of Experimental Biology, the scientists reconstructed the flight behaviour of the common mayfly, filming large swarms in the London borough of Richmond in 3D and analysing the insects’ flight paths.

In further simulations, the scientists found that male mayflies would stop their pursuit of any target that dropped beneath the horizon

“The problem is that the males have almost no filter,” Fabian says. “You can give them a beach ball – which, as far as I’m concerned, looks quite different from a female mayfly – and males will go right up to that much larger object and try to mate with it.”

Things get even trickier in low-light conditions, as females look almost identical to males even at close range. By staying below the females, males ensure their romantic energy is well spent. This is especially critical because mayflies do not have much time, only living from a few hours to a few days, during which they must pass on their genes.

Acing such reproductive goals is crucial to the species’ long-term survival. There are more than 3,000 mayfly species living in the world’s freshwater creeks, rivers, ponds and lakes. But many of Britain’s 51 species are now in a state of decline – another victim of what scientists call the “insect apocalypse”.

2019 global review estimated that 40% of the world’s insects were declining, while another study suggests more than 1 in 10 species could be lost by the end of the century.

From 2015 to 2021, the nonprofit conservation group WildFish carried out a riverfly census of Britain’s chalk streams. These streams are some of the cleanest waterways, fed by cool springs that flow from aquifers through chalk, a form of limestone. The species that live here are often very sensitive to pollution.

The census found that Britain’s chalk streams had lost 41% of their mayfly species on average compared with 1998. “In many lowland catchments, the spectacular hatches that once defined early summer have diminished dramatically, reflecting decades of mounting pressure on freshwater ecosystems,” says Janina Gray, head of science and policy at WildFish. “Pollution, sediment runoff, reduced river flows and rising water temperatures are all eroding the conditions these insects depend on.”

Other research suggests that even modest pollution in many English rivers may be enough to kill up to 80% of mayfly eggs, laid in riverbeds.

For now, Fabian encourages Britons to relish the ancient spectacle while they still can.

“This behaviour is something that pretty much everyone, at certain times of the year, should be able to see,” he says.

“These are quite urban places with lots of traffic, but they’re still hanging on and they’re still doing this dance that they have probably been doing since before Britain was separated from mainland Europe.”

The Guardian

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