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What you need to know before taking weight-loss drugs

Weight-loss drugs are not the quick fix solution that many people believe, especially if you hope to keep the pounds off in the long-term.

Sarah Le Brocq has direct experience of the transformative effects of weight-loss drugs. She has lived with obesity for most of her adult life and tried numerous diets. “Anything that came out, I thought, ‘I’ll try that because that might work for me’.” Unfortunately, the weight always came back, she told the BBC’s Inside Health.

After taking weight-loss drugs for more than two years, she has lost almost eight stone (51kg/112lb). “All of a sudden I wasn’t thinking about food anymore,” she says. “I’ve just got more energy, I’m doing things I couldn’t do before… it’s kind of given me a new freedom in life again.”

Millions of people like Sarah are now accessing medications like semaglutide and tirzepatide, better known by their popular brand names Ozempic and Mounjaro. The numbers of people on weight-loss medication is only likely to increase as new drugs appear on the market too, including pills rather than the current jabs.

It’s clear that these drugs are opening up a new era in the treatment of obesity. The condition, is now a “mitigatable” issue, David Cummings, professor of medicine at the University of Washington tells me. “They are the closest thing I’ve seen to miracle drugs”. 

Other academics, however, warn that we risk losing sight of the need for behavioural change, especially as weight tends to be regained quickly when people stop taking the drugs.

So what should anyone planning to use weight-loss medication consider before they start?

How they work

Weight-loss drugs work by suppressing an individual’s appetite by mimicking hormones that tell our body when it is full. The most common are known as glucagon-like peptide 1, or GLP-1, and glucose-dependent insulinotropic polypeptide, or GIP.

The drugs bind to specialised molecules on the surface of our cells known as GLP-1 and GIP receptors, which play a key role in telling our body when it has had enough food.

Typically someone taking these drugs will begin to lose weight within the first few weeks. Although the drugs are only approved for weight loss in people with obesity, there is a rapidly growing private market for those not considered clinically obese.

Their popularity has been rising because they are extremely effective, with weight loss of between 14-20% in 72 weeks. But about 10-15% of people lose very little weight, so called “non-responders“.

GLP-1s are like “a chemical shield” that protects individuals against our “modern obesogenic environment, filled with cheap, calorie-dense foods”, says Naveed Sattar, a professor of cardiometabolic medicine at the University of Glasgow and leads the UK Government’s Obesity Healthcare Goals programme. He has also consulted on medical trials with several companies who produce weight-loss drugs but does not own any shares.

“There’s food everywhere,” he says – and within half an hour anyone “can pick up the phone and order 10,000 calories of food”.

If you stop, you’ll gain weight

If someone living with obesity starts to take weight-loss drugs, they need to consider that they may be on the drug long-term, says Cummings, who runs a weight management programme for individuals with obesity who have BMIs of 50 and above.

A common question he is asked by his patients before they start taking a weight-loss drug is how long they will be on it. Typically, they stop taking the drugs after about a year, he says. One analysis of scientific studies involving more than 9,000 patients indicated the average treatment duration was 39 weeks. People believe they can continue to lose weight using their willpower, he says, but the evidence suggests that is not the case.

People stop for various reasons, either due to the expense of treatment, their insurers stopping coverage or individuals not wishing to be on drugs for a prolonged period of time, Cummings has found.

And when people do stop the drugs, their weight tends to rebound. A recent study found that weight regain happens up to four times more quickly after stopping weight-loss drugs compared to someone ending a weight-loss programme that focuses on changing their behaviour.

Another study found that those on weight-loss drugs gained 1.5kg (3.3lbs) eight weeks after they stopped the medication, with their weight continuing to climb with the more time that passed. The same study also found that other health concerns, such as high blood pressure, also returns. New research has also found that people who stop taking weight-loss drugs gain back around 60% of the weight they lost a year later.

It returns quickly because of something researchers call “food noise“, which consists of persistent and intrusive thought around food, says Sattar.

Hormones play a role too. When an individual tries to lose weight, it triggers a powerful hormonal response that tells your body to regain the weight you lost. Cummings explains that because of this, the brain interprets a calorie drop as an energy deficiency, so after stopping weight-loss drugs, hormones that stimulate appetite increase while the rate at which you burn energy – the metabolic rate – decreases. “If these biological defences are strong enough, they can blunt the drug’s effectiveness,” he says.

Lifestyle change

Sattar has observed that for a small proportion of people who make lifestyle changes, it may be possible to reduce the dose or use the drug intermittently instead. Some really do make “fundamental changes in their diet”, he says.

“Others might need it at a lower dose than they would when they started. But the majority will probably still need some dose of the drug because the [food] environment is still the same.”

There’s also increasing concern that individuals are taking weight-loss medication as a substitute for making life-style changes – even though evidence shows that modifying lifestyle in combination with weight-loss drugs is what will lead to greater weight loss.

Experts have recently cautioned in a scientific review of the evidence that when there’s a lack of behavioural and lifestyle support for those on weight-loss drugs, it can leave individuals vulnerable to nutritional deficiencies. “We need to make sure people are getting enough protein and are getting all the vitamins and minerals they need,” says Marie Spreckley a nutrition and behavioural scientist at Cambridge University and lead author of the report. “You don’t want to have longer-term unintended consequences, like frailty and muscle loss. We don’t want to replace one health concern with another.”

Because these medications cause a dramatic appetite reduction, patients tend to eat less overall, she and her colleagues note. This can lead to a “missed opportunity” if patients are not supported long-term and their food choices remain poor.

No quick fix

The World Health Organization has therefore stated that medication alone won’t “reverse the obesity challenge”. Early interventions, screening and creating healthier environments are also needed, the organisation has stated in its guidelines on using GLP-1 drugs.

This is easier when people are still taking the drugs, Sattar says. “You have more mental space to think about your diet.”

But behavioural change is extremely challenging, says Amanda Daley, a professor of behavioural medicine at Loughborough University in the UK. She says there needs to be better communication with patients about how quickly they can regain weight once they stop taking GLP-1 medication.

Obesity is a chronic, relapsing condition, she says, which means it cannot be “cured” with a drug alone. That’s why additional support and “wraparound care” is key to ensure patients make dietary changes as well as increasing their physical activity.

It’s unclear whether private providers are providing this crucial additional support, she says, which she finds concerning since so many people access the drugs privately and it is hard to monitor continuation of care.

Micro-nudges help change behaviour

To overcome some of this – researchers at Stanford have looked at how they can help support and encourage lifestyle changes. In one recent study, researchers tested whether small nudges – or “microsteps” – could help encourage healthy behavioural change for those taking GLP-1 medications.

The tiny changes focused on nutrition, physical activity, sleep and stress management. Crucially, the microsteps were small and manageable, such as swapping sugary drinks for water, no longer drinking coffee after lunch, taking a deep breath when stressed or popping outside for five minutes.

They found these helped improve behavioural expectations. It’s this “expectation” that’s a first necessary step for behavioural change, says Maya Adam, a clinical associate professor of paediatrics at Stanford School of Medicine, who was involved in the study.

“Achieving your best health involves a lot more than pharmacotherapy alone,” she says. “We found that giving people these little nudges may be very effective.” She calls these steps “too small to fail” because even small daily changes and habits make a real difference over time.

Side-effects

These kind of interventions are crucial to help give people the tools they need to enact change, Daley says, especially considering the known side effects. These include gastrointestinal issues. There has also been an observed increase in pancreatitis and gallstones. Muscle loss is another concern, especially among individuals who are not exercising. Recently a study found links to bone and joint conditions too.

While we now have several years of data on the effectiveness of GLP-1 drugs, we don’t yet know what the long-term outlook will be or whether the results will wear off over time. There is also a lack of data on how these drugs affect pregnancy outcomes or future generations, as the advice is not to take weight-loss drugs during pregnancy. 

But given the negative health outcomes for those living with obesity, the side effects pale in comparison, both Sattar and Cummings say. This is particularly the case for individuals with multiple weight-related conditions. Heart disease, cancer and stroke are the leading causes of death worldwide – and all are linked to obesity.

A changing landscape

What is clear is that the landscape for weight-loss medication is rapidly evolving.

There are other health benefits too beyond weight loss. In one major study involving two million people, the drugs were linked to better heart health, fewer infections, lower risk of drug abuse and lower incidences of dementia. It’s also been shown to improve sleep apnoea, arthritis and substance abuse. 

BBC

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NMC Speciality Hospital, Al Nahda successfully treats Rare case of Guillain – Barré Syndrome in an 11 – Month old Infant

Dubai, UAE – A multidisciplinary medical team at NMC Specialty Hospital, Al Nahda has successfully treated an 11-month-old infant diagnosed with Guillain–Barré syndrome (GBS), specifically acute motor axonal neuropathy (AMAN), variant, enabling the infant to make a complete recovery.

The infant, who was previously healthy, was brought to NMC Specialty Hospital after developing severe irritability and an inability to bear weight following a recent viral illness. Recognising that these symptoms could indicate a serious underlying neurological condition, specialists initiated a comprehensive assessment, leading to the diagnosis of acute motor axonal neuropathy (AMAN), a rare variant of Guillain–Barré syndrome.

Guillain–Barré syndrome is an autoimmune neurological disorder in which the body’s immune system mistakenly attacks the peripheral nervous system. While it can affect individuals of all ages, it is rarely reported in infants younger than one year often making diagnosis particularly challenging.

The case was led by Dr. Krupa Torne, Paediatric Neurologist, and involved close collaboration among experts from Paediatrics, Neuroradiology, Neurophysiology, Physiotherapy and Nursing. The coordinated efforts of the multidisciplinary team enabled a prompt diagnosis and immediate initiation of treatment with intravenous immunoglobulin (IVIG) therapy, which is considered one of the most effective interventions for Guillain–Barré syndrome when administered early.

“The rarity of Guillain–Barré syndrome in infants can make diagnosis difficult, as symptoms may initially be mistaken for more common childhood illnesses,” said Dr. Krupa Torne. “In this case, the early recognition of neurological symptoms, combined with rapid multidisciplinary assessment and treatment, played a crucial role in achieving an excellent outcome. It highlights the importance of maintaining a high index of suspicion for neurological conditions even in very young children.”

Following treatment, the infant was closely monitored and underwent physiotherapy to support recovery and mobility. Over the following weeks, the infant demonstrated steady neurological improvement, regaining strength and motor function.

At the eight-week follow-up appointment, the infant was able to walk independently and showed a completely normal neurological examination, marking a full recovery.

The successful outcome underscores the importance of access to specialist paediatric neurological expertise and integrated multidisciplinary care in managing complex and rare childhood conditions.

“This case reflects the strength of collaborative care and the advanced capabilities available at NMC Specialty Hospital, Al Nahda,” said Dr. Torne. “When specialists across disciplines work together seamlessly, we can deliver timely, evidence-based treatment that significantly improves outcomes for our youngest and most vulnerable patients.”

The infant’s parents expressed their heartfelt gratitude to the entire medical team, acknowledging the compassionate care, clinical expertise and unwavering support that helped their infant make a full recovery.

NMC Specialty Hospital, Al Nahda continues to provide comprehensive paediatric care supported by advanced diagnostic capabilities and specialised clinical expertise, helping patients with both common and complex conditions achieve the best possible outcomes.

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Breastfeeding: The First Gift That Lasts a Lifetime By Dr. Mamata Bothra
Specislist Pediatrician & Pediatric Neurologist at International Modern Hospital Dubai

WORLD BREASTFEEDING WEEK (1st–7th August)

Breastfeeding: The First Gift That Lasts a Lifetime By Dr. Mamata Bothra
Specislist Pediatrician & Pediatric Neurologist at International Modern Hospital Dubai

It’s 2 a.m. Your newborn has just fed… again. Grandma thinks the baby is still hungry. Google says one thing. Instagram says another. A well-meaning aunt suggests formula. Dad is trying to make tea while wondering if babies actually sleep. And you’re asking yourself… “Doctor… am I doing something wrong?” If this sounds familiar, welcome to parenthood! Every year, from 1st to 7th August, the world celebrates World Breastfeeding Week, a global campaign coordinated by the World Alliance for Breastfeeding Action (WABA) in partnership with the World Health Organization (WHO)and UNICEF. It is a reminder that while breastfeeding is the most natural way to nourish a baby, it is not always easy—and no mother should have to do it alone. This year’s World Breastfeeding Week theme is “Breastfeeding for a Sustainable Start in Life: Strengthen What Works”. announced by WABA reinforcing the global commitment to protect, promote and support breastfeeding through families, healthcare systems, workplaces and communities. The WHO recommends exclusive breastfeeding for the first six months of life, followed by appropriate complementary foods while continuing breastfeeding up to two years of age or beyond, as long as mother and child wish. Here in the UAE, where families come from every corner of the world, I meet new parents every day who bring different traditions, beliefs and advice from home. Yet despite our diverse cultures, the questions are surprisingly similar—and so are the worries. The Golden Hour… One Hour That Can Change a Lifetime One of the most beautiful moments in medicine happens quietly. A newborn is placed on the mother’s chest immediately after birth. The baby slowly lifts the head, searches, and instinctively finds the breast. No instructions. No YouTube videos. No parenting apps. Just nature doing what it has perfected over millions of years. This precious first hour, known as the Golden Hour, helps regulate the baby’s temperature, breathing and blood sugar while strengthening the bond between mother and baby. It also encourages successful breastfeeding and improves long-term health outcomes. Then come those precious first drops of milk—colostrum. Often called Nature’s First Vaccine, colostrum is rich in antibodies, immune cells and growth factors that protect babies from infections and help build a healthy immune system from the very first day of life. More Than Food… Breastfeeding is Love in Its Purest Form Breastfeeding isn’t simply about filling a tiny stomach. It comforts a frightened baby. Calms pain after a vaccination. Provides warmth during illness. Strengthens emotional security. And quietly builds the baby’s brain and immune system with every single feed. Research continues to show that breastfed babies have lower rates of diarrhea, pneumonia, ear infections, allergies, obesity, diabetes and several chronic diseases later in life. Breastfeeding has also been linked with improved cognitive development and emotional wellbeing. The benefits don’t stop with babies. For mothers, breastfeeding helps the uterus recover after delivery, reduces postpartum bleeding, supports recovery, and lowers the long-term risk of breast cancer, ovarian cancer, type 2 diabetes and heart disease. Simply put… Breastfeeding is one of the few interventions that improves the health of two people at the same time. Confessions from a Pediatrician’s Clinic… After years of caring for newborns, I’ve noticed something rather amusing. The babies are usually quite relaxed. It’s the parents who look like they’ve just sat for an exam they never prepared for! Every clinic day begins with questions like… “Doctor, my baby wants milk every hour.” “Doctor, my milk looks watery.” “Doctor, my breasts suddenly feel soft… has my milk dried up?” “Doctor, it’s so hot in Dubai. Should I give water?” “Doctor… everyone at home has a different opinion!” My answer usually starts with a smile. “Congratulations! Your baby is behaving exactly like… a baby.” Let’s Clear Up Some Common Confusion Newborns have tiny stomachs,Breast milk is digested quickly, so feeding every one to three hours is completely normal. Frequent feeding does not mean your milk is inadequate; it is simply how babies stimulate the body to produce more milk. One of the conversations I have almost every day with new mothers begins with the same worry: “Doctor, I don’t think I have enough milk.” I gently reassure them, “No mother starts with bottles full of milk on the first day.” Nature doesn’t work that way. In the first few days after birth, your body produces small amounts of colostrum—those precious golden drops often called nature’s first vaccine. Although the quantity seems tiny, it is exactly what your newborn needs because a baby’s stomach is small initially. As your baby suckles more frequently, your body receives the signal to produce more milk. It’s a beautiful demand-and-supply system—the more effectively the baby feeds, the more milk is produced. Over the next few days, your milk gradually increases to meet your baby’s growing needs. One of the most fascinating aspects of breastfeeding is that breast milk is uniquely designed for your own baby. It changes not only from one month to another, but from one feed to the next, and even during the course of the day. It provides the perfect balance of water, nutrients, healthy fats, proteins, antibodies, hormones and immune factors that your baby needs at that particular stage of growth. Nature truly has no better nutritionist than a mother’s own body. Living in the UAE, another concern I hear almost daily is whether babies need water during our intense summer heat. The answer is reassuring. Healthy babies who are exclusively breastfed do not need additional water during the first six months of life—even during the UAE summer. Breast milk is nearly 88% water and provides all the hydration a healthy infant requires. Many mothers also worry when their breasts begin to feel softer after a few weeks. That is actually good news. It usually means your body has become more efficient at making milk—not that the milk has disappeared. And then there are grandparents… Bless them! Their advice comes from love. Sometimes… not from science. “Your milk looks thin.” “The baby cried once—give formula.” “The baby isn’t sleeping for four hours.” Fortunately, babies don’t judge milk by its appearance. Breast milk naturally changes throughout a feed. The early milk ( foremilk)satisfies thirst, while the richer hindmilk provides energy and healthy fats. Nature got it right long before social media arrived. Seven Practical Tips Every New Parent Should Know 1. Watch your baby—not the clock.
Feed when your baby shows hunger cues such as rooting, sucking on hands or lip smacking.Check for activity, cry and hydration. 2. Count wet diapers—not opinions.
Six or more urine wet diapers each day after first few days usually indicate good feeding. 3. Every baby is different.
Please don’t compare your baby’s feeding with your neighbour’s baby. 4. Ask for help early.
A painful latch can usually be corrected quickly if addressed early. 5. Stay hydrated and nourished.
A healthy mother is better equipped to care for a healthy baby. 6. Rest whenever you can.
Laundry will wait. Babies won’t. 7. Trust yourself.
Mothers often know their babies better than they realise. Dear Fathers… This Part Is Especially for You You may not be able to breastfeed. But you can become the greatest breastfeeding supporter in the house. Bring her water. Prepare a meal. Change nappies. Rock the baby after feeds. Protect her rest. Tell her she’s doing an incredible job. Sometimes the best breastfeeding support doesn’t come from milk. It comes from love. When Should You Call Your Pediatrician? Seek medical advice if your baby is unusually sleepy, refusing feeds, passing fewer than six wet diapers after the first week, developing fever, persistent jaundice or poor weight gain. Mothers should also seek help if breastfeeding is persistently painful, if there is breast redness, fever or concerns regarding milk supply. Remember… Most breastfeeding challenges are temporary. Most can be solved. And most mothers simply need reassurance rather than replacement feeding. A Message to Every Mother Dear Mum, If you’ve ever cried because breastfeeding felt difficult… If you’ve doubted yourself… If you’ve searched Google at 3 a.m.… If you’ve wondered whether you’re enough… Please know this. You are learning. So is your baby. Give yourselves grace. Because breastfeeding isn’t about perfection. It’s about patience, practice and love. As pediatricians, we prescribe antibiotics, inhalers and medicines every day. But perhaps the most powerful prescription we can ever write for a new mother is confidence. To simply look at her and say… “You’re doing better than you think.” This World Breastfeeding Week, let us replace myths with science, criticism with encouragement, and pressure with compassion. Because breastfeeding is not merely the baby’s first meal. It is the first vaccine. The first cuddle. The first comfort. The first promise of lifelong health. “When we support breastfeeding, we don’t just nourish one baby—we build a healthier generation, one family at a time.” Happy World Breastfeeding Week! “A mother’s confidence is often the best medicine a newborn can receive. Support her, encourage her, and together we give every child the healthiest possible beginning.” — Dr. Mamata Bothra, Specialist Pediatrician & Neonatologist

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Fakeeh Health Achieves National Institute for Health Specialties (NIHS) Institutional Accreditation for Residency Training

Fakeeh Health Achieves Institutional Accreditation from the National Institute for Health Specialties (NIHS) for Residency Training

Dubai, UAE – 13 July 2026

Fakeeh Health has been awarded the Institutional Accreditation by the National Institute for Health Specialties (NIHS), reinforcing its position as one of the UAE’s academic healthcare providers and marking another important milestone in its commitment to postgraduate medical education and the development of future specialist physicians. Dr. Mohammed Al Houqani, Secretary General of NIHS, presented the Institutional Accreditation certificate to Fakeeh University Hospital (FUH), noting that this accreditation demonstrates FUH’s compliance with rigorous national standards in postgraduate medical education (PGME). He said he was delighted to see a private hospital actively contributing to healthcare workforce development, adding that academic hospitals play an important role in improving healthcare by integrating clinical care, education, research and continuous quality improvement. The accreditation has been awarded to Fakeeh Health, encompassing FUH together with its network of Fakeeh Medical Centers, recognizing the organization as an approved institution for PGME training in the United Arab Emirates. This achievement follows the successful accreditation of Fakeeh University Hospital’s Medical Internship Program.

The National Institute for Health Specialties (NIHS) is the UAE’s national authority responsible for regulating and accrediting postgraduate medical education and residency training. Institutions awarded NIHS Institutional Accreditation are recognized for meeting rigorous national standards in educational governance, faculty development, resident support, patient safety, clinical learning environments, quality improvement and competency-based medical education.

For Fakeeh Health, the accreditation represents far more than regulatory recognition. It reflects the strength of an integrated academic ecosystem designed to prepare the next generation of physicians through structured residency programs, multidisciplinary clinical exposure and a culture of continuous learning across its healthcare network.

The comprehensive accreditation process assessed multiple aspects of the organization’s educational framework, including institutional leadership and governance, faculty engagement, resident wellbeing, assessment systems, research opportunities, simulation-based education, patient safety, quality improvement initiatives and the overall clinical learning environment.

Since launching its postgraduate medical education programs in collaboration with Dubai Health Authority in 2021, Fakeeh Health has steadily expanded its academic portfolio. Through structured residency and internship programs, competency-based education, faculty development initiatives and simulation-enhanced learning, the organization continues to invest in preparing highly skilled physicians capable of meeting the evolving healthcare needs of the UAE.

Residents training within Fakeeh Health benefit from diverse clinical experiences across Fakeeh University Hospital and its network of Fakeeh Medical Centers, allowing them to gain exposure to primary, secondary and tertiary care while learning within a patient-centered environment that promotes teamwork, innovation and evidence-based practice.

The accreditation also supports the UAE’s long-term vision of developing a sustainable national healthcare workforce and further strengthens Dubai’s position as a regional centre for advanced medical education and specialist training.

Dr. Mazen Fakeeh, Chairman Fakeeh Health, said:

“At Fakeeh Health, we believe that shaping the future of healthcare begins with investing in people. Educating and mentoring the next generation of physicians is one of our greatest responsibilities, and this accreditation reflects years of commitment to building an academic environment where education, clinical excellence and innovation work together. We are proud to contribute to the UAE’s vision of developing a highly skilled healthcare workforce while continuing to raise the standards of medical education across the region.”

Dr. Mohaymen Abdelghany, Group CEO & Board Member Fakeeh Health, and CEO Fakeeh University Hospital, said::

“This accreditation is an achievement for every member of the Fakeeh Health family. It reflects the dedication of our physicians, educators, faculty members and support teams who have worked together to create an outstanding learning environment for future specialists. By investing in high-quality medical education today, we are helping shape the physicians who will care for the communities of tomorrow. We will continue expanding our academic programs, strengthening clinical training and creating opportunities that enable future healthcare professionals to thrive.”

Dr. Mazen Abou Chaaban, Designated Institutional Official (DIO), said:

“Institutional Accreditation is an important validation of the strength of our educational governance, faculty engagement and learning culture. More importantly, it confirms that we have created an environment where residents are supported academically, professionally and personally throughout their training. Our goal is not only to develop competent specialists, but also compassionate physicians who embrace lifelong learning, professionalism and patient-centered care.”

Fakeeh Health expressed its appreciation to the National Institute for Health Specialties for its guidance throughout the accreditation process and acknowledged the dedication of its physicians, faculty members, educators, administrators and support teams whose collective efforts made this achievement possible.

Looking ahead, Fakeeh Health will continue expanding its residency and postgraduate medical education programs while strengthening academic collaborations, research and innovation across its healthcare network. The organization remains committed to preparing the next generation of healthcare professionals and supporting the UAE’s ambition to become a global leader in healthcare, medical education and clinical excellence.

About Fakeeh Health

Fakeeh Health is an integrated academic healthcare network comprising Fakeeh University Hospital and a growing network of Fakeeh Medical Centers across the UAE. By combining world-class patient care with medical education, research and innovation, Fakeeh Health is committed to developing future healthcare professionals while delivering exceptional, patient-centered care across every stage of the healthcare journey.

Academic Excellence at a Glance

NIHS Institutional Accreditation for Residency Training

NIHS-accredited Medical Internship Program

More than 600 undergraduate healthcare students trained annually

Structured residency, internship and clinical training programmes

Strong partnerships with leading national and international universities and healthcare institutions

Ongoing commitment to developing the UAE’s future healthcare workforce

For more information please visit our website:

https://www.fakeeh.health
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